Research Associate II
Summary of Position
Quiver is seeking a highly motivated Research Associate to join our Imaging Group. The Research Associate will execute high-quality functional phenotypic measurements using Quiver’s proprietary Firefly instruments, Optopatch assays, and other custom instrumentation for disease-modeling and drug discovery. The Research Associate will also assist with cell and molecular biology-related tasks (basic cell culture, DNA and RNA preparations, and qPCR assays) as well maintenance of Quiver’s custom instruments.
Responsibilities and Duties
- Support the following functional imaging activities:
- Review experimental design forms and communicate changes when necessary
- Preparation of metadata excel file and plate map files
- Perform all-optical electrophysiology recordings of neuronal cultures
- Generation of preliminary results with MATLAB
- Prepare and manage inventory of large batches of imaging buffers for Optopatch measurements.
- Organizing on-line imaging and instrument schedule.
- Assist in day-to-day preparation of screening instrumentation.
- Use liquid handling system for plate washing and compound loading.
- Generation and implementation of Standard Operating Procedures and management of imaging operations including inventory and re-stocking of supplies.
- Log results and processes electronically.
- Assist the Biology Team with human stem cell culture, neuronal production and culture, nucleic acid preparations and quantitative PCR assays.
- Collaborate with the Analysis Team in processing and QC of functional movie files and report generation.
- Communicate work results via technical reports and PowerPoint presentations.
- Assist Engineering Team with QC of functional imaging instruments.
- Assist with compound handling tasks including preparation of compound stocks and near assay-ready plates.
Minimum Qualifications Required
- A Bachelor’s degree in chemistry, biology, biotechnology, bioengineering or a related field.
- Experience operating scientific, medical, engineering instrumentation or equivalent.
- Experience working in a laboratory setting and performing routine laboratory procedures
- Ability to work independently and in cross-disciplinary teams
- Excellent oral, written and interpersonal communication skills
Additional Qualifications Desired
- Experience reading and editing code in MATLAB
- Knowledge of electrophysiology is a plus
- Experience with imaging assays is a plus
- Experience will cell culture, 96/384-well assays, and high-throughput screening is a plus